abstract：:Sendide is a selective and extremely potent antagonist of neurokinin-1 (NK1) receptors in the mouse spinal cord. The antinociceptive activities of sendide, an antagonist of NK1 receptors, and its analogue, [D-Trp7]sendide have been examined after intrathecal (i.t.) administrations in the mouse paw formalin test. Intra...

journal_title：Pain

authors： Sakurada T,Katsumata K,Yogo H,Tan-No K,Sakurada S,Ohba M,Kisara K

更新日期：1995-02-01 00:00:00

abstract：:Mechanisms of hypnotic analgesia were investigated by examining changes in the R-III, a nociceptive spinal reflex, during hypnotic reduction of pain sensation and unpleasantness. The R-III was measured in 15 healthy volunteers who gave VAS-sensory and VAS-affective ratings of an electrical stimulus during conditions o...

journal_title：Pain

authors： Kiernan BD,Dane JR,Phillips LH,Price DD

更新日期：1995-01-01 00:00:00

abstract：:Tolerance to the antinociceptive (analgesic) effect of morphine, a mu-opioid agonist, was developed in male CD-1 mice as assessed by a shift to the right of the analgesic (tail-flick) dose-response curves and an increase in the ED50 values. Administration of dextromethorphan at 30 mg/kg s.c., but not saline, 30 min pr...

journal_title：Pain

authors： Elliott K,Hynansky A,Inturrisi CE

更新日期：1994-12-01 00:00:00

abstract：:The clinical and neurochemical association between depression and season noted in seasonal affective disorder (SAD) has suggested that clinical pain might also be linked to season, perhaps through similar neurochemistry or the known association of depression with pain. We investigated the pain-light season/dark season...

journal_title：Pain

authors： Hawley DJ,Wolfe F

更新日期：1994-11-01 00:00:00

abstract：:We report on a patient suffering severe pain following a long-standing sacral chordoma in whom management of therapy and pain was extremely difficult. Because orally administered morphine was observed to be ineffective in the early stages of treatment, we tried to achieve pain relief by using epidural morphine. This w...

journal_title：Pain

authors： Aguilar JL,Espachs P,Roca G,Samper D,Cubells C,Vidal F

更新日期：1994-11-01 00:00:00

abstract：:The responses of preterm neonates to acute tissue-damaging stimuli have been described. However, factors which influence these responses have received little attention. In this study, we observed 124 premature infants before, during and after a routine heel lance and determined how two contextual variables (severity o...

journal_title：Pain

authors： Stevens BJ,Johnston CC,Horton L

更新日期：1994-10-01 00:00:00

abstract：:The presence of a trigger point is essential to the myofascial pain syndrome. This study centres on identifying clearer criteria for the presence of trigger points in the quadratus lumborum and gluteus medius muscle by investigating the occurrence and inter-rater reliability of trigger point symptoms. Using the sympto...

journal_title：Pain

authors： Hua NK,Van der Does E

更新日期：1994-09-01 00:00:00

abstract：:Is a person's response to one noxious stimulus similar to his/her responses to other noxious stimuli? This long-investigated topic in pain research has provided inconclusive results. In the present study, 2 samples were studied: one using 60 healthy volunteers and the other using 29 patients with coronary artery disea...

journal_title：Pain

authors： Janal MN,Glusman M,Kuhl JP,Clark WC

更新日期：1994-09-01 00:00:00

abstract：:Two hundred and sixty-three ambulatory patients older than 21 years of age who were attending clinics at an oncology hospital in San Juan, Puerto Rico, were studied. They completed a questionnaire (BQ-PR) that measures 8 concerns about reporting pain and using analgesics, such as fears of addiction and tolerance and t...

journal_title：Pain

authors： Ward SE,Hernandez L

更新日期：1994-08-01 00:00:00

abstract：:Using a number of complementary anatomical and molecular techniques, we studied the effects of chronic constriction injury (CCI), a model of partial nerve injury that elicits behavioral hyperalgesia, on primary sensory neurons in the rat. Dorsal root ganglia taken from animals with CCI were analyzed for alterations in...

journal_title：Pain

authors： Nahin RL,Ren K,De León M,Ruda M

更新日期：1994-07-01 00:00:00

abstract：:Unilateral intraplantar injection of Freund's complete adjuvant (FCA) into 1 hind paw of rats was used as a model of peripheral inflammation and persistent pain in order to examine time course effects of a continuous barrage of nociceptive input on the second-messenger transducing systems in the spinal cord. cAMP, cGM...

journal_title：Pain

authors： Igwe OJ,Li N

更新日期：1994-07-01 00:00:00

abstract：:Acute inflammation of the sigmoid wall was induced by perendoscopic injection of formalin (50 microliters, 5%) under brief anesthesia in rats. The procedure was followed by behavioral patterns that significantly differed from those in animals injected with isotonic saline instead of formalin. Analysis of the formalin-...

journal_title：Pain

authors： Miampamba M,Chéry-Croze S,Gorry F,Berger F,Chayvialle JA

更新日期：1994-06-01 00:00:00

abstract：:Low Back Pain Rating scale is an index scale which includes measurements of pain intensity, disability, and physical impairment. The scale was designed to monitor the outcome of clinical trials of low back pain treatment. It has been validated in 58 patients following first-time discectomy. The scale rating can be rap...

journal_title：Pain

authors： Manniche C,Asmussen K,Lauritsen B,Vinterberg H,Kreiner S,Jordan A

更新日期：1994-06-01 00:00:00

abstract：:Percutaneous radiofrequency lumbar facet denervation has been in use as a treatment for intractable, mechanical low back pain for over 2 decades. A number of case series have been reported with high rates of success in selected patients; however, there has been limited objective outcome assessment, long-term follow-up...

journal_title：Pain

authors： North RB,Han M,Zahurak M,Kidd DH

更新日期：1994-04-01 00:00:00

abstract：:The responses of primate spinothalamic tract (STT) neurons to innocuous and noxious mechanical stimuli applied to the skin can be enhanced for more than an hour following prolonged noxious stimulation. This increased responsiveness is thought to reflect sensitization of dorsal horn neurons and may help account for sec...

journal_title：Pain

authors： Paleček J,Palečková V,Dougherty PM,Willis WD

更新日期：1994-03-01 00:00:00

abstract：:The present report describes a nation-wide survey on the incidence, the indications and the efficacy of spinal cord stimulation (SCS), as assessed by the Belgian health authorities. The direct motive for this survey was the rapidly growing expenditures resulting from the increasing use of SCS. Between 1983 and 1992, n...

journal_title：Pain

authors： Kupers RC,Van den Oever R,Van Houdenhove B,Vanmechelcn W,Hepp B,Nuttin B,Gybels JM

更新日期：1994-02-01 00:00:00

abstract：:Previous animal and human studies have indicated that nociceptive thresholds are decreased by acute hyperglycemia. The results of these studies may be challenged due to methodological problems. We therefore conducted a double-blind, controlled, cross-over study on the effect of acute hyperglycemia on nociceptive and n...

journal_title：Pain

authors： Thye-Rønn P,Sindrup SH,Arendt-Nielsen L,Brennum J,Hother-Nielsen O,Beck-Nielsen H

更新日期：1994-01-01 00:00:00

abstract：:An experimental mononeuropathy was produced in rats by unilateral loose ligation of the sciatic nerve, with a contralateral sham surgery. Repeated bilateral sensory testing was performed over time to investigate any threshold differences between the loose ligature side and the contralateral control side. A prolonged r...

journal_title：Pain

authors： Kingery WS,Castellote JM,Wang EE

更新日期：1993-12-01 00:00:00

abstract：:Coeliac plexus block (CPB) is one of the few neurolytic procedures that is still considered very useful in managing chronic cancer pain. We describe what we believe to be the fifth case in the literature of paraplegia following coeliac plexus block with ethyl alcohol. Clinical and neurophysiological examination confir...

journal_title：Pain

authors： De Conno F,Caraceni A,Aldrighetti L,Magnani G,Ferla G,Comi G,Ventafridda V

更新日期：1993-12-01 00:00:00

abstract：:Genetic influence on the sensory, motor and histopathological outcome of transient spinal cord ischemia was studied in Sprague-Dawley (SD), spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Ischemia caused minor motor deficits and no identifiable morphological damage in the spinal cord of the majority of SD...

journal_title：Pain

authors： Wiesenfeld-Hallin Z,Hao JX,Xu XJ,Aldskogius H,Seiger Å

更新日期：1993-11-01 00:00:00

abstract：:This study aimed to identify areas of disagreement in the management of neurogenic pain. A short questionnaire was mailed to 179 consultants with an interest in chronic pain (response rate 89%). The questionnaire listed 11 specific conditions involving nerve pain (e.g., post-herpetic neuralgia, causalgia) together wit...

journal_title：Pain

authors： Davies HTO,Crombie IK,Macrae WA

更新日期：1993-09-01 00:00:00

abstract：:After a pilot study had indicated that the topical application of guanethidine might be of value in the treatment of tooth dentine hypersensitivity, a double-blind study was undertaken to investigate whether guanethidine was more effective than a distilled water control in alleviating dentinal pain. In 39 adult subjec...

journal_title：Pain

authors： Dunne SM,Hannington-Kiff JG

更新日期：1993-08-01 00:00:00

abstract：:This study evaluated two brief (3-5 min) interventions for controlling responses to acute pain. Eighty male subjects were randomly assigned to 1 of 2 intervention groups (Positive Emotion Induction (PEI) or Brief Relaxation (BR)) or to 1 of 2 control groups (No-instruction or Social Demand). The PEI focused on re-crea...

journal_title：Pain

authors： Bruehl S,Carlson CR,McCubbin JA

更新日期：1993-07-01 00:00:00

abstract：:The responses of 144 spinothalamic tract (STT) cells were recorded in 15 anesthetized macaque monkeys (Macaca fascicularis). Three to 4 weeks prior to the acute experiment, the sciatic nerve was surgically exposed on one or both sides so that capsaicin or vehicle could be applied. Responses of STT cells recorded in 3 ...

journal_title：Pain

authors： Chung JM,Paik KS,Kim JS,Nam SC,Kim KJ,Oh UT,Hasegawa T,Chung K,Willis WD

更新日期：1993-06-01 00:00:00

abstract：:In the skin surrounding a site of injury, hyperalgesia develops to mechanical stimuli. Two types of secondary hyperalgesia (to light touch and punctate stimuli) have recently been differentiated, based on different durations and sizes of the area involved. We studied secondary hyperalgesia in a subject who had a loss ...

journal_title：Pain

authors： Treede RD,Cole JD

更新日期：1993-05-01 00:00:00

abstract：:In order to clarify the mechanism of reference of pain following cordotomy (ROPC), the authors investigated ROPC in 66 patients undergoing percutaneous cervical cordotomy (PCC) and examined the features of ROPC and the correlation between the occurrence of ROPC and the pre-operative pain states, as well as the results...

journal_title：Pain

authors： Nagaro T,Amakawa K,Kimura S,Arai T

更新日期：1993-05-01 00:00:00

abstract：:In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spont...

journal_title：Pain

authors： Lin JC,Tsao WL,Lee HK,Wang Y

更新日期：1993-04-01 00:00:00

abstract：:Tricyclic antidepressants (TCAs) have been found to be useful in the management of a variety of chronic pain conditions, although there is little published regarding the potential efficacy of this class of drug as an adjunct for the control of acute postoperative pain and related symptoms. Twenty-eight patients underg...

journal_title：Pain

authors： Kerrick JM,Fine PG,Lipman AG,Love G

更新日期：1993-03-01 00:00:00

abstract：:There is considerable evidence to implicate N-methyl-D-aspartate (NMDA) receptor activation in the mechanisms that underly thermal hyperalgesia in the spinal cord. As many of the effects of NMDA receptor activation appear to be ultimately mediated through production of nitric oxide (NO), recent reports have begun to d...

journal_title：Pain

authors： Meller ST,Gebhart GF

更新日期：1993-02-01 00:00:00

abstract：:Preliminary reports have shown that hyperbaric oxygen (HBO) interrupts cluster headache (CH) attacks. In the present study, 6 of 7 patients with episodic cluster headache who were treated with hyperbaric oxygen experienced an interruption of the attack. In 3 of 6 responders the florid period of the cluster headache wa...

journal_title：Pain

authors： Di Sabato F,Fusco BM,Pelaia P,Giacovazzo M

更新日期：1993-02-01 00:00:00

abstract：:Adrenal medullary transplants in the spinal subarachnoid space, by providing a continual source of opioid peptides and catecholamines, offer a potentially important adjunct in the management of chronic pain. While previous studies have shown that this approach is effective against high-intensity phasic stimuli, adrena...

journal_title：Pain

authors： Hama AT,Sagen J

更新日期：1993-02-01 00:00:00

abstract：:A wide range of environmental stimuli have been shown to induce antinociception. Investigation of the brain regions contributing to environmentally induced antinociception (EIA) has focused primarily on the effect of disrupting neural transmission at various CNS sites. In contrast, the present study analyzed changes i...

journal_title：Pain

authors： Morgan MM,Fields HL

更新日期：1993-01-01 00:00:00

abstract：:In a double-blind placebo-controlled cross-over study the effects of epidural morphine (4 mg) on somatosensory functions were investigated in 10 healthy volunteers. Detection, pain detection and pain tolerance thresholds to thermal, mechanical and electrical stimuli as well as magnitude rating of short-lasting stimuli...

journal_title：Pain

authors： Brennum J,Arendt-Nielsen L,Horn A,Secher NH,Jensen TS

更新日期：1993-01-01 00:00:00

abstract：:Bradykinin is an endogenous peptide that is thought to be a chemical mediator of the hyperalgesia following inflammation. In rat, bradykinin has been postulated to cause hyperalgesia to mechanical stimuli by releasing prostaglandin from sympathetic post-ganglionic terminals. The aim of this study was to determine whet...

journal_title：Pain

authors： Meyer RA,Davis KD,Raja SN,Campbell JN

更新日期：1992-12-01 00:00:00

abstract：:The effects of intrathecal administration of substance P and N-methyl-D-aspartate (NMDA) were studied in the formalin test in mice. Both substances were administered 5 min before injection of formalin into the hind paw. Co-administration of substance P and NMDA intensified the response in both the 1st (0-10 min) and t...

journal_title：Pain

authors： Mjellem-Joly N,Lund A,Berge OG,Hole K

更新日期：1992-11-01 00:00:00

abstract：:Involvement of the NMDA receptor system in the transmission of nociceptive information, including the development of central sensitization and a wind-up phenomenon, has increased interest in NMDA-receptor antagonists as antinociceptive drugs. This case report describes the use of an NMDA receptor antagonist 3-(2-carbo...

journal_title：Pain

authors： Kristensen JD,Svensson B,Gordh T Jr

更新日期：1992-11-01 00:00:00

abstract：:Previous research has demonstrated that intravenously administered cannabinoids produce potent antinociception in rodents. The present study examined the ability of 16 cannabinoid analogs to produce antinociception and hypothermia after intrathecal administration. Fifteen of the compounds tested produced significant i...

journal_title：Pain

authors： Lichtman AH,Smith PB,Martin BR

更新日期：1992-10-01 00:00:00

abstract：:Effects of electrical stimulation of the cervical vagus nerve were determined in cervical or lumbar spinal neurons in 27 rats anesthetized with pentobarbital. Ipsilateral cervical vagus stimulation (ICVS) increased activity of 44 neurons in the C1 segment. At the same stimulation parameters, contralateral cervical vag...

journal_title：Pain

authors： Qing-Gong F,Chandler MJ,McNeill DL,Foreman RD

更新日期：1992-10-01 00:00:00

abstract：:Intraperitoneal administration of the serotonin 5-HT1A agonist, buspirone (1-5 mg/kg), produced dose- and time-related core hypothermia that was coincident with analgesia against a thermally noxious stimulus. Surface body temperature was not altered by buspirone. The 5-HT1A antagonist, NAN-190 (2 mg/kg, s.c.), blocked...

journal_title：Pain

authors： Giordano J,Rogers L

更新日期：1992-09-01 00:00:00

abstract：:The effectiveness of a brief clinical and basic science seminar on pain for 1st year medical students was examined by comparing attitudes about pain prior to the seminar to attitudes 5 months after the seminar. The 6-h course combined written materials conveying facts about behavioral, social and biological aspects of...

journal_title：Pain

authors： Wilson JF,Brockopp GW,Kryst S,Steger H,Witt WO

更新日期：1992-09-01 00:00:00